Three different songs have been used in the anime of Monochrome Factor: one opening theme and two ending themes. The opening theme is "Metamorphose" by Asriel and written by Kokomi. The first ending theme is "Awake ~Boku no Subete~" by Daisuke Ono (Akira Nikaido) and Kamiya Hiroshi (Kengo Asamura) while the second ending theme is "Kakusei ~Dark and Light~" by Konishi Katsuyuki (Kou) and Junichi Suwabe (Shirogane). Both songs are performed by the characters' seiyūs in the Japanese anime.
Each character has their own drama CD and a character theme.
- "Destiny" by Daisuke Ono, the seiyū for Akira.
- "Crystallize" by Junichi Suwabe, the seiyū for Shirogane.
- "The World of Tomorrow" by Kamiya Hiroshi, the seiyū for Kengo.
- "Dive" by Konishi Katsuyuki, the seiyū for Kou.
- "Monochrome" by Wataru Hatano, the seiyū for Shuichi Wagatsuma.